Prey 2 may be developed by Arkane Studios, and be at Bethesda's E3 2016 Presentation.
Both Kotaku and a Prey fansite, Aliennoire, have hinted at the possibility that Prey 2 will be back at E3. This time it's being developed by Arkane Studios, the developers behind Dishonored, instead of Human Head Studios.
While the fan site has speculated that the announcement date will be June 14, it sounds much more likely that it will happen on June 12, as this is the day of the Bethesda's E3 press conference. The fan site has also said the game is being developed by Arkane Studios, which is far more likely due to some leaked emails -- which came out in mid-2013 -- backing this up.
Raphael Colantonio, the Co-Creative Director at Arkhane alongside Harvey Smith, sent out an email in May of 2013 stating that the team in Austin had been greenlit on a project surrounding Prey.
This information was swiftly leaked, and Colantonio sent out a follow up email.
Will Prey 2 now be Dishonored in space? That doesn't sound bad at all.